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How does heroin affect the brain and body?

Heroin binds to opioid receptors in the brain, reducing pain and creating euphoria, but it also suppresses breathing and can impair judgment and coordination.

And over time, the brain adapts, making it harder to feel normal without the drug.

Right, and that adaptation is what drives tolerance — the brain starts requiring more of the drug just to achieve the same effect, which raises overdose risk.

That loss of feeling “normal” often affects daily functioning. Basic tasks, relationships, and decision-making can start revolving around avoiding withdrawal rather than personal goals.

It’s not just the brain either. Chronic use can weaken the immune system and strain organs, making people more vulnerable to infections and long-term health problems.

What’s happening neurologically is that the brain’s natural reward system becomes less responsive, so everyday pleasures stop registering the way they used to.

As the brain and body change, priorities often shift too, which can lead to isolation as work, family, and social ties take a back seat.